Welcome to the Erwin Lab at Baylor College of Medicine!

We study the functional role of repetitive DNA, the final frontier of the human genome.

Welcome to the Erwin Lab at Baylor College of Medicine!

We study the functional role of repetitive DNA, the final frontier of the human genome.

Team Members of the Erwin Lab from June 2024
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Tandem repeat diseases

ribbon, as a symbol of the fight against cancer

Cancer

100101 as a graphical representation of bioinformatics

Bioinformatics and genome biology

graphical representation of a molecule

Drug discovery

Publications

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The design and development of synthetic transcription elongation factors.

Erwin et al, & Ansari. Science 2017.

Neurodegen. Disease

Recurrent repeat expansions in human cancer genomes.

Erwin et al, & Snyder. Nature 2023.

Genome Biology

Genome-wide mapping of programmable DNA binders.

Erwin et al, & Ansari. PNAS 2016.

Chemical Biology

Video

Featured Video

Meet our team members

Graham Erwin

Graham Erwin

PRINCIPAL INVESTIGATOR

Graham likes studying repetitive DNA, synthesizing molecules to target repetitive DNA, and bringing people together to talk about repetitive DNA. He organizes the Structural Variants and DNA Repeats (SVAR) Conference every year. Outside of the lab, he recently instituted a no-repeats policy to his athletic endeavors, and now runs, bikes, and swims on different days. He also explores generative AI and teaches evidence-based breathwork and meditation courses.

Lucas Finot

Lucas Finot

BIOINFORMATICIAN

Lucas is a recent graduate deeply interested in the insights offered by next-generation sequencing. While Lucas’s background might not be in biology, he possesses a strong affinity for solving intricate problems, particularly those involving our body—an area he finds profoundly intriguing. Beyond the lab, Lucas enjoys engaging in new sports and hobbies, with current passions including Muay Thai, baking, and cooking. His pursuit of diverse interests highlights a versatile approach to both scientific exploration and personal growth.

Layne Lavicky

Layne Lavicky

POSTDOCTORAL RESEARCHER

Layne is interested in repeat expansion disorders. She completed her PhD at University of Oklahoma Health Sciences Center where she studied genetic and epigenetic mechanisms in Friedreich ataxia. Outside of the lab, you will find her playing frisbee with her dog, Henry, or exploring Houston’s restaurant scene.

Lauren Masters

Lauren Masters

GRADUATE STUDENT

Lauren is a graduate student in the Cancer & Cell Biology program here at Baylor Medicine. In the lab she is working on cancer genetics and understanding the mechanisms of extrachromosomal DNA (ecDNA). She graduated with a B.S. from The Ohio State University in Molecular Genetics and has research experience in epigenetics and SARS-CoV-2 sequencing. In her free time she enjoys working out, reading, traveling, and exploring Houston.

Ananya Vadlakonda

Ananya Vadlakonda

RESEARCH TECHNICIAN

Ananya completed her undergraduate work at Case Western Reserve University (CWRU), studying Biology with minors in Chemistry, Sociology, and Public Health. Her previous research experiences included studying dendritic cells in immune-related diseases at CWRU and studying tandem repeats at Stanford University. She’s excited to continue working on uncovering the molecular functions of tandem repeats to ultimately develop targeted therapeutics for tandem repeat-mediated diseases. In her free time, Ananya loves to write, dance, and go on long walks.

Cera Aex

Cera Aex

UNDERGRAD STUDENT

Cera is currently an undergraduate student at the University of Louisiana at Lafayette pursuing degrees in Biology with a concentration in Microbiology and in Chemistry. They have research experience with transcription factor interactomes and genetic adaptation in plants, and their current research interests include cancer genomics and genetic regulation. In their free time, Cera loves to play a variety of tabletop and video games, and they enjoy learning new recipes to cook and bake.

Nathan Bui

Nathan Bui

UNDERGRAD STUDENT

Nathan is an undergraduate student at Rice University studying BioSciences and Neuroscience. His past research experience involves IDH1/IDH2 mutations in glioblastoma as well as light-driven optic gliomagenesis. In the lab, he is investigating the role and mechanism of tandem repeats in Friedrich Ataxia. Outside of the lab, Nathan enjoys weightlifting, swimming, cooking, and drawing!

Abigail King

Abigail King

UNDERGRAD STUDENT

Abi is a student at Rice University studying Biosciences with a concentration in cellular biology and genetics. In the lab, she is currently investigating the tissue specificity of repeat expansions and gene expression in Fuch’s endothelial corneal dystrophy (FECD), and her long-term goal is to pursue a career researching the mechanisms behind eye diseases and visual impairment with the hope that one day her research will have clinical applications. She is also part of the Rice Women’s Swim Team, so outside of the lab you will probably find her at the pool. She also enjoys reading, hiking, and live music.

Maha Razzaq

Maha Razzaq

UNDERGRAD STUDENT

Maha Razzaq is a rising sophomore at Rice University studying (maybe) Computer Science and Economics! She has diverse interests ranging from Environmental Policy to Epidemiology to Genetics. In the lab, Maha hopes to implement data analysis techniques to learn more about short tandem repeat (STR) expansions and their relation to genetic disorders and cancer. Maha is also practically a Houston native, having been here for nearly 10 years! In her free time, she enjoys baking, running, and learning about random things!

Stella Son

Stella Son

UNDERGRAD STUDENT

Stella is an undergraduate student at Rice University studying Biosciences with a Major Concentration in Cell Biology and Genetics with a minor in Medical Humanities. She previously worked in an immunology lab that focused on the application of dendritic cells in immunotherapies against cancer. She’s excited to conduct research on tandem repeat diseases, such as Fragile X Syndrome, and work towards finding potential treatments. In her free time, she enjoys weightlifting, reading, and trying out new restaurants.

Kaitlyn Wong

Kaitlyn Wong

UNDERGRAD STUDENT

Kaitlyn is a student at Indiana University Bloomington, studying Molecular Life Sciences, Chemistry, and East Asian Languages & Cultures. With research experience in the #FlowerLab@IU on the development of nectaries in flowers, she is currently investigating tandem repeats in breast cancer in the Erwin Lab. Kaitlyn’s long-term goal is to pursue a career in research, striving to see firsthand how scientific discoveries translate into tangible benefits for human health. Outside of the lab, Kaitlyn is a running enthusiast, an avid reader, a violinist, and finds joy in learning new things.

Join Us

Join a project. Or design your own.

Graduate students

Graduate students interested in the Erwin Lab should contact Graham to discuss rotation projects. He will be a mentor in both the Genetics & Genomics, and Cancer & Cell Biology Programs. Students in other programs are welcome and encouraged to rotate for their third or fourth rotations.

Postgraduates

We are recruiting researchers who recently graduated or are about to graduate and would like to participate in an immersive two-year research experience prior to pursuing an advanced degree or a role in industry. To apply, please email Graham a cover letter, your CV, and the names of two to three references.

Postdoctoral researchers

Prospective postdoctoral researchers who are about to receive their Ph.D. and/or M.D., or equivalent in genetics, neuroscience, molecular biology, chemistry, bioinformatics, or a related field are especially encouraged. There are multiple, funded positions in the lab to pursue exciting questions in repetitive DNA. To apply, please email Graham a cover letter, your CV, and the names of three references.

Undergraduate students

We are always looking for motivated undergraduate students to join the lab! If interested, please send Graham a copy of your transcript along with a statement (usually 2-3 paragraphs long) explaining why you are interested in joining the lab.

Get in touch today

ASSISTANT PROFESSOR
DEPARTMENT OF MOLECULAR AND HUMAN GENETICS
BAYLOR COLLEGE OF MEDICINE

1 Baylor Plaza
Houston, TX 77030

Want to reach out directly?

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graham.erwin@bcm.edu
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@grahamserwin